Richard B Silverman Selected Research

Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)

1/2022	2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.
1/2022	Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS).
1/2020	First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
1/2019	Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.
11/2018	Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides.
11/2017	Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
11/2017	Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
1/2016	Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
11/2015	Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.
2/2015	Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.

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Richard B Silverman Research Topics

Disease

30	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 12/2004
15	Epilepsy (Aura) 12/2021 - 09/2002
10	Parkinson Disease (Parkinson's Disease) 10/2019 - 01/2012
7	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 08/2015
6	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 08/2015 - 01/2012
5	Nervous System Diseases (Neurological Disorders) 01/2022 - 03/2007
5	Infantile Spasms (West Syndrome) 12/2021 - 01/2012
5	Seizures (Absence Seizure) 12/2021 - 01/2012
5	Huntington Disease (Huntington's Disease) 05/2015 - 12/2012
5	Cerebral Palsy (Spastic Diplegia) 10/2012 - 02/2009
4	Melanoma (Melanoma, Malignant) 05/2022 - 08/2013
4	Neoplasms (Cancer) 01/2021 - 12/2004
4	Cocaine-Related Disorders (Cocaine Addiction) 10/2020 - 01/2012
4	Substance-Related Disorders (Drug Abuse) 01/2018 - 09/2002
4	Hypoxia (Hypoxemia) 10/2012 - 02/2009
4	Ischemia 10/2012 - 02/2009
4	Brain Injuries (Brain Injury) 01/2011 - 02/2009
3	Neuralgia (Stump Neuralgia) 01/2021 - 10/2014
3	Pain (Aches) 01/2020 - 09/2012
3	Gaucher Disease (Gaucher's Disease) 01/2019 - 09/2016
2	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 04/2015
2	Lewy Body Disease (Lewy Body Dementia) 01/2019 - 09/2016
2	Synucleinopathies 01/2019 - 09/2016
2	Asphyxia (Suffocation) 08/2014 - 12/2013
2	Stroke (Strokes) 01/2013 - 03/2008
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2010 - 02/2006
1	Skin Neoplasms (Skin Cancer) 05/2022
1	Myoclonus (Nocturnal Myoclonus) 12/2021
1	Temporal Lobe Epilepsy 12/2021
1	Amyloid Plaque 01/2021
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2021
1	Arthritis (Polyarthritis) 01/2020
1	Heart Failure 01/2020
1	Sepsis (Septicemia) 01/2020
1	Inflammation (Inflammations) 01/2020
1	Endotoxemia 01/2020
1	Liver Neoplasms (Liver Cancer) 10/2019
1	Breast Neoplasms (Breast Cancer) 01/2019
1	Inborn Genetic Diseases (Disease, Hereditary) 09/2016
1	Adenoma (Adenomas) 04/2016
1	Gliosis 11/2015
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 11/2015
1	Body Weight (Weight, Body) 11/2015
1	Osteoporosis 01/2015
1	Infections 01/2015
1	Brain Ischemia (Cerebral Ischemia) 01/2015

Drug/Important Bio-Agent (IBA)

27	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 01/2022 - 03/2007
13	gamma-Aminobutyric Acid (GABA)IBA 12/2021 - 09/2002
12	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2022 - 05/2007
10	Pharmaceutical PreparationsIBA 05/2022 - 09/2002
9	EnzymesIBA 01/2021 - 05/2007
9	4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)IBA 10/2020 - 09/2002
7	Vigabatrin FDA Link 12/2021 - 09/2002
7	Protein Isoforms (Isoforms)IBA 01/2020 - 05/2007
7	Nitric Oxide Synthase (NO Synthase)IBA 01/2015 - 05/2007
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 12/2004
5	Ornithine-Oxo-Acid Transaminase (Ornithine Aminotransferase)IBA 01/2022 - 08/2015
5	Neurotransmitter Agents (Neurotransmitter)IBA 10/2020 - 04/2006
5	AcidsIBA 01/2018 - 01/2012
4	PyridoxalIBA 01/2021 - 01/2018
4	Aminobutyrates (Aminobutyric Acid)IBA 10/2020 - 01/2012
4	Glucosylceramidase (Glucocerebrosidase)IBA 10/2019 - 09/2016
4	Sirtuin 2IBA 05/2015 - 12/2012
3	polyglutamineIBA 11/2015 - 04/2014
3	pyrazoloneIBA 08/2015 - 01/2012
3	Superoxide Dismutase-1IBA 08/2015 - 01/2012
3	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 07/2013 - 01/2012
2	Peptides (Polypeptides)IBA 05/2022 - 02/2006
2	Anticonvulsants (Antiepileptic Drugs)IBA 12/2021 - 01/2018
2	Transaminases (Aminotransferases)IBA 01/2021 - 01/2012
2	CalciumIBA 01/2021 - 06/2013
2	Calcium Channels (Calcium Channel)IBA 01/2021 - 06/2013
2	Arginine (L-Arginine)FDA Link 01/2020 - 08/2013
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2020 - 11/2010
2	(1S,3S)- 3- amino- 4- difluoromethylenecyclopentanecarboxylic acidIBA 01/2018 - 03/2007
2	DNA (Deoxyribonucleic Acid)IBA 08/2015 - 02/2006
2	sansalvamide AIBA 01/2010 - 02/2006
1	Fluorescein-5-isothiocyanate (FITC)IBA 05/2022
1	Peptide LibraryIBA 05/2022
1	Interferon-gamma (Interferon, gamma)IBA 01/2022
1	Pentylenetetrazole (Metrazol)IBA 12/2021
1	Amyloid (Amyloid Fibrils)IBA 01/2021
1	Glutamine (L-Glutamine)FDA Link 01/2021
1	OrnithineIBA 01/2021
1	Proline (L-Proline)FDA Link 01/2021
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2019
1	Mutant Proteins (Protein, Mutant)IBA 01/2019
1	Organic Chemicals (Chemicals, Organic)IBA 11/2018
1	AldosteroneIBA 04/2016
1	Ataxin-3IBA 11/2015
1	Citalopram FDA LinkGeneric 11/2015
1	SaltsIBA 08/2015
1	AminesIBA 08/2015
1	Superoxide DismutaseIBA 08/2015
1	PyrazolonesIBA 08/2015
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2015
1	CholesterolIBA 01/2015
1	alpha-SynucleinIBA 01/2015

Therapy/Procedure

10	Therapeutics 12/2021 - 02/2006
2	Drug Therapy (Chemotherapy) 05/2022 - 01/2021